ConsExpo nano

Input

Local file management

Info message

The input you have entered on this page has been stored in a file, which you can upload at a later time using the Import button.

Hazard study

Include results of a hazard study in rats, for comparison

Monte Carlo simulation

The number of iterations to be performed. Select a number between 100 and 10 000.
Number of iterations

Output options

Dose normalisation
Human
1. Body weight (kg)
2. Lung weight (g)
3. Alveolar area (m²)
4. Number of alveoli
5. Number of alveolar macrophages
Rat
1. Body weight (g)
2. Lung weight (g)
3. Alveolar area (m²)
4. Number of alveoli
5. Number of alveolar macrophages

Exposure

Scenario

Name or description (optional)
Scenario type
- Spray scenario
- Custom scenario
Exposure duration (min)
Air concentration (mg/m³)

Aerosol

Density aerosol particle (g/cm³)
Weight fraction nano material in aerosol particle
Aerosol diameter Type of distribution
1. Aerosol diameter (mass median) (µm)
2. Arithmetic coefficient of variation
3. Maximum aerosol diameter (µm)
4. distribution:
  If you want to use a non-parametric aerosol particle size distribution, you must first upload a distribution file.

Load default scenario from factsheet

First, select a factsheet, then a product

Factsheet
Product

Spray

Mass generation rate (g/s)
Weight fraction nanomaterial in product
Airborne fraction

Usage

Spray duration (s)
Spraying towards exposed person
1. Cloud volume (m³)

Room

Room volume (m³)
Room height (m)
Ventilation rate (per hour)

Nanomaterial

Name or description (optional)
Density nanomaterial (g/cm³)
Type of distribution
1. Arithmetic coefficient of variation
Shape nano particle
1. Nano particle diameter (nm)
2. Nano particle height (nm)
3. Nano particle thickness (nm)
4. Nano particle surface area (single-sided) (nm²)
Nanomaterial soluble
1. Dissolution rate (per day)

Simulation

Exposure Pattern
1. Exposure frequency unit
2. Exposure frequency
3. Number of exposure events
Simulation duration (days)
Deposition model
Inhalation rate (m³/h)

Hazard study (in rats)

Exposure

Air concentration (mg/m³)
Aerosol diameter Type of distribution
1. Aerosol diameter (mass median) (µm)
2. Geometric standard deviation (GSD)
3. Maximum aerosol diameter (µm)
Density aerosol particle (g/cm³)
Deposition fraction of the aerosol
Inhalation rate (m³/h)
Number of days exposed
Exposed hours per day
Simulation duration (days)

Nanomaterial

Name or description (optional)
Density nanomaterial (g/cm³)
Shape nano particle
1. Nano particle diameter (nm)
2. Nano particle height (nm)
3. Nano particle thickness (nm)
4. Nano particle surface area (single-sided) (nm²)
Nanomaterial soluble
1. Dissolution rate (/day)

You may upload a particle size distribution, e.g. based on measured data.

To describe the distribution, the total range that the particle diameter takes on, is subdivided in a set of bins. For each bin, the amount of particles with diameter in that bin is specified as the fraction of the total spray mass of these particles.

To upload a non-parametric distribution, a text file should be prepared according to the following format:

The file should contain two headerless columns, separated by a single 'tab'.
The first column specifies the diameter bin as the upper bound of the size bin in µm. The lower bound of the bin is assumed to be the upper bound of the previous bin. The lower bound for the first bin is taken to be 0.
The second column should contain the fraction of the total mass in the bin. If the total fraction of all bins is larger than 1, the distribution will automatically be normalized to 1 on import. A total fraction < 1 is accepted as valid input, however.
Separating decimals can be done using either ',' or '.' as a separator.

Upload a aerosol diameter distribution file Select a file:

The upload failed.

ConsExpo nano RIVM, https://www.consexponano.nl version 3.1, 15-08-2024

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